DNA Pol III Beta Site Inhibitor Project

The target for this project is the beta site on DNA polymerase III. Several key proteins involved in DNA replication and repair bind at this site.

We have identified several lead series that bind at this target which display broad spectrum antibiotic activity from MIC of 1 ug/ml upwards.

We are currently conducting further studies to optimise the efficacy and absorption of current leads and are seeking further funding to enable optimisation and selection of a development candidate.