Betathera is focussed on the discovery and development of novel antibiotics with low resistance potential

Recent Work

Through DNA-encoded (DEL) and high-throughput screening, we have discovered lead compounds acting at the β site on DNA polymerase III. Initial studies have shown these to have broad spectrum antibiotic activity on Gram negative and Gram negative bacteria and studies are continuing to further validate these leads and progress them to development candidates.

DNA Pol III Beta Site Inhibitor Project

The β subunit of DNA Pol III forms a dimer surrounding the bacterial DNA chain. Other proteins involved in DNA replication and repair then bind to the β site on Pol III as a common anchor to enable progression of DNA replication. The β subunit is the green protein in this animation of bacterial DNA replication.